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Merck

420307

Kallikrein, Human Plasma

Native Kallikrein from human plasma. A serine protease that releases bradykinin from kininogen. Present in the plasma as an inactive precursor, prokallikrein.

Synonym(s):

Kallikrein, Human Plasma, Kininogenin, Kininogenase

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About This Item

CAS Number:
9001-01-8
EC Number:
3.4.21.34 (BRENDA, IUBMB)
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00131428

Key Documents

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Product Name

Kallikrein, Human Plasma, Native Kallikrein from human plasma. A serine protease that releases bradykinin from kininogen. Present in the plasma as an inactive precursor, prokallikrein.

biological source

human plasma

description

Merck USA index - 14, 5279

assay

≥95% (SDS-PAGE)

form

liquid

specific activity

≥15 units/mg protein

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

storage temp.

−20°C

Quality Level

100

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Harmful (C)

General description

Native Kallikrein from human plasma. A serine protease that releases bradykinin from kininogen. Present in the plasma as an inactive precursor, prokallikrein.

Other Notes

One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol D-Pro-Phe-Arg-pNA per min at 25°C, pH 8.0.
Pu, X., et al. 1994. Biochim. Biophys. Acta 1208, 338.
Nagase, H. and Barrett, A.J. 1981. Biochem. J.193, 187.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In NaCl and Tris-HCl buffer.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ning Luan et al.
Toxins, 11(12) (2019-12-11)
Elastase is a globular glycoprotein and belongs to the chymotrypsin family. It is involved in several inflammatory cascades on the basis of cleaving the important connective tissue protein elastin, and is strictly regulated to a balance by several endogenous inhibitors.

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