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Merck

421050

(Z-LL)2 Ketone

A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide without affecting the activities of signal peptidases and other proteases.

Synonym(s):

(Z-LL)2 Ketone, 1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone

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About This Item

Empirical Formula (Hill Notation):
C43H64N6O9
Molecular Weight:
809.00
UNSPSC Code:
12352200

Product Name

(Z-LL)2 Ketone, A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide without affecting the activities of signal peptidases and other proteases.

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Analysis Note

single spot by TLC

Biochem/physiol Actions

Cell permeable: no
Primary Target
Processing of the p-Prl signal peptide
Product does not compete with ATP.
Reversible: no
Target IC50: ~ 50 nM inhibiting the processing of the p-Prl signal peptide

Disclaimer

Toxicity: Standard Handling (A)

General description

A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)2 ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.

Other Notes

Weihofen, A., et al. 2002. Science296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
Z-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Youngkyung Cho et al.
BMC biology, 18(1), 60-60 (2020-06-05)
Epithin/PRSS14, a type II transmembrane serine protease, is an emerging target of cancer therapy because of its critical roles in tumor progression and metastasis. In many circumstances, the protease, through its ectodomain shedding, exists as a soluble form and performs

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