421050
(Z-LL)2 Ketone
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide without affecting the activities of signal peptidases and other proteases.
Synonym(s):
(Z-LL)2 Ketone, 1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
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About This Item
Empirical Formula (Hill Notation):
C43H64N6O9
Molecular Weight:
809.00
UNSPSC Code:
12352200
Quality Level
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)2 ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Processing of the p-Prl signal peptide
Processing of the p-Prl signal peptide
Product does not compete with ATP.
Reversible: no
Target IC50: ~ 50 nM inhibiting the processing of the p-Prl signal peptide
Packaging
Packaged under inert gas
Analysis Note
single spot by TLC
Other Notes
Weihofen, A., et al. 2002. Science296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
Z-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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