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Merck

422500

Kifunensine, Kitasatosporia kifunense

A potent alkaloid inhibitor of mannosidase I.

Synonym(s):

Kifunensine, Kitasatosporia kifunense

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About This Item

Empirical Formula (Hill Notation):
C8H12N2O6
CAS Number:
109944-15-2
Molecular Weight:
232.19
MDL number:
MFCD00270017
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Kifunensine, Kitasatosporia kifunense, A potent alkaloid inhibitor of mannosidase I.

SMILES string

N21[C@H](NC(=O)C2=O)[C@H]([C@H]([C@@H]([C@H]1CO)O)O)O

InChI

1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1

InChI key

OIURYJWYVIAOCW-PQMKYFCFSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

hot water: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
mannosidase-1
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent alkaloid inhibitor of mannosidase I. An ineffective inhibitor of mannosidase II and the endoplasmic reticulum α-mannosidase.

Other Notes

Weng, S., and Spiro, R.G. 1996. Arch. Biochem. Biophys.325, 113.
Kayakiri, H., et al. 1991. Chem. Pharm. Bull. 39, 1378.
Elbein, A.D., et al. 1990. J. Biol. Chem. 265, 15599.
Iwami, M., et al. 1987. J. Antibiotic. 40, 612.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Merve Sen et al.
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Rhodopsin (RHO) misfolding mutations are a common cause of the blinding disease autosomal dominant retinitis pigmentosa (adRP). The most prevalent mutation, RHOP23H, results in its misfolding and retention in the endoplasmic reticulum (ER). Under homeostatic conditions, misfolded proteins are selectively

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