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422625

KLF5 Inhibitor, CID 5951923

Name: KLF5 Inhibitor, CID 5951923
Brand: MM

The KLF5 Inhibitor, CID 5951923 controls the biological activity of KLF5.

Synonym(s):

KLF5 Inhibitor, CID 5951923, 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₈N₂O₇S

CAS Number:

749872-43-3

Molecular Weight:

382.39

UNSPSC Code:

12352200

NACRES:

NA.28

MDL number:

MFCD04796932

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Quality Segment

100

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S]1(=O)(=O)CC(CC1)N(C)C(=O)COC(=O)\C=C\c2cc(ccc2)[N+](=O)[O-]

InChI

1S/C16H18N2O7S/c1-17(14-7-8-26(23,24)11-14)15(19)10-25-16(20)6-5-12-3-2-4-13(9-12)18(21)22/h2-6,9,14H,7-8,10-11H2,1H3/b6-5+

InChI key

URVRJYLSUVXWBC-AATRIKPKSA-N

Description

General description

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC₅₀ = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr¹⁰⁶⁸ and ERK1/2-Thr²⁰²/Tyr²⁰⁴. Also, up-regulates the phosphorylation of p38 MAPK-Thr¹⁸⁰/Tyr^182.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.

Other Notes

Bialkowska, A., et al. 2011. Mol. Cancer Ther.10, 2043.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c