437600
LPD-12
A water soluble, amphiphilic α-helical lipopeptide detergent (LPD) that forms small micelles and effectively mimics lipid bilayers.
Synonym(s):
LPD-12, Lipopeptide Detergent-12, Ac-AO(C12)AEAAEKAAKYAAEAAEKAAKAO(C12)A-NH2
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About This Item
Empirical Formula (Hill Notation):
C131H224N32O37
Molecular Weight:
2839.37
UNSPSC Code:
12352200
Quality Level
assay
≥95% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
CMC
<1 μM
solubility
water: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A water soluble, amphiphilic α-helical lipopeptide detergent (LPD) that forms small micelles and effectively mimics lipid bilayers (solubility in PBS ~ 40 mM; micelle MW ~ 23,100; aggregation number ~ 8.1; partial specific volume ~ 0.77 cm3/g). Shown to not only solubilize but also stabilize bacteriorhodopsin, lactose permease and E. coli PagP protein ([LPD] ~ 250 µM and [protein] ~ 22 µM) by forming complexes and precluding aggregation. Useful for NMR and X-ray structural studies of membrane proteins.
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ac-Ala-Orn(dodecanoyl)-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Lys-Tyr-Ala-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Lys-Ala-Orn(dodecanoyl)-Ala-NH₂
McGregor, C.L., et al. 2003. Nat. Biotechnol.21, 171.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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