438075
Longdaysin
A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIα and CKIδ activities with moderate selectivity over Cdk7 and Erk2.
Synonym(s):
Longdaysin, 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine, Casein Kinase I Inhibitor VII, Casein Kinase I Inhibitor VII, 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine
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About This Item
Empirical Formula (Hill Notation):
C16H16F3N5
CAS Number:
Molecular Weight:
335.33
UNSPSC Code:
12352200
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
2-8°C
General description
A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIα and CKIδ activities (IC50 = 5.6 and 8.8 µM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52 µM). Shown to block CKIα/δ-mediated phosphorylation of PER1, a clock protein, (IC50 ~ 9 µM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~ 13 hrs at 10 µM) much more effectively than Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) and IC261 (Cat. No. 400090 ) and in larval zebra fish.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Hirota, T., et al. 2010. PLoS Biol.8, e1000559.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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