440203
LY 303511
A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002.
Synonym(s):
LY 303511, 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V
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About This Item
Empirical Formula (Hill Notation):
C19H18N2O2
CAS Number:
Molecular Weight:
306.36
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze
Quality Segment
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
amber
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C19H18N2O2/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13,20H,9-12H2
InChI key
NGAGMBNBKCDCDJ-UHFFFAOYSA-N
General description
A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC50 ~10 µM).
A cell-permeable, negative control for the phosphatidylinositol-3-kinase (PI-3 kinase) inhibitor, LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not affect PI-3 kinase activity even at concentrations ≥100 µM.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Negative control for the PI 3-kinase inhibitor LY 294002
Negative control for the PI 3-kinase inhibitor LY 294002
Product does not compete with ATP.
Reversible: no
Target IC50: Does not inhibit PI 3-kinase even at a concentration of 100 µM
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Dittman, et al. 2014. ACS Chem Biol.9, 495.
Ding, J., et al. 1995. J. Biol. Chem.270, 11684.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
Ding, J., et al. 1995. J. Biol. Chem.270, 11684.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
Certificates of Analysis (COA)
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