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444221

Sigma-Aldrich

MMP-1/MMP-9 Substrate

≥95% (HPLC), Fluorescent MMP Substrate, solid

Synonym(s):

MMP-1/MMP-9 Substrate, Fluorogenic

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About This Item

Empirical Formula (Hill Notation):
C49H68N14O12S
Molecular Weight:
1077.22
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

MMP-1/MMP-9 Substrate, Fluorogenic, An excellent quenched fluorescence substrate for MMP-1 and MMP-9.

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

50% acetic acid: 10 mg/mL

fluorescence

λex ~365 nm
λem ~450 nm

shipped in

ambient

storage temp.

−20°C

General description

An excellent quenched fluorescence substrate for MMP-1 and MMP-9 (excitation maximum: 365 nm; emission maximum: 450 nm). Both enzymes cleave this substrate between Gly and Cys(Me), liberating a fluorescent cleavage product. Suitable for inhibitor screening and determining Ki values. Excitation max: ~365 nm; emission max: ~450 nm.

Biochem/physiol Actions

Cell permeable: no
Primary Target
MMP-1, MMP-9
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Other Notes

Bickett, D.M., et al. 1993. Anal. Biochem. 212, 58.
{DNP-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH₂[Cha = β-cyclohexylalanyl; Abz = 2-aminobenzoyl (anthraniloyl)]

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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