MMP Inhibitor Set I

Contains 5 mg each of MMP-2/MMP-9 Inhibitor I (Cat. No. 444241) and MMP-3 Inhibitor II (Cat. No. 444225), and 1 mg each of GM 6001 (Cat. No. 364205), GM 6001, Negative Control (Cat. No. 364210), and MMP-8 Inhibitor I (Cat. No. 444237).

Matrix metalloproteinases (MMP) are a family of zinc-dependent enzymes that include interstitial collagenases, stromelysins, gelatinases, and membrane-type metalloproteinases. They are part of the intricate extracellular matrix (ECM) and are involved in maintaining the integrity of the ECM by removing undesired proteins. MMPs play a key role in the normal physiology of connective tissue during development, morphogenesis, and wound healing. However, the unregulated activity of MMPs has been implicated in a number of disease processes, including arthritis, tumor cell metastasis, and atherosclerosis. As a result of their involvement in various disease states, MMPs have become a target for the development of potential therapeutic inhibitors.



The Calbiochem brand has assembled a convenient set containing 4 inhibitors (and one negative control) with different specificities for the study of the biological activity of MMPs and the physiological mechanisms of MMP activation and inhibition.

Primary Target
MMP

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C).

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)