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Merck

444282

MMP/TACE Substrate, FS-6

The widely used MMP substrate FS-1 is modified by an N-terminal lysine elongation to produce a broad-spectrum MMP and TACE substrate that displays improved water solubility and substrate sensitivities.

Synonym(s):

MMP/TACE Substrate, FS-6, Mca-KPLG~L-Dpa-AR-NH2

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About This Item

Empirical Formula (Hill Notation):
C55H80N16O16
Molecular Weight:
1221.32
NACRES:
NA.77
UNSPSC Code:
12352200

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Product Name

MMP/TACE Substrate, FS-6, The widely used MMP substrate FS-1 is modified by an N-terminal lysine elongation to produce a broad-spectrum MMP and TACE substrate that displays improved water solubility and substrate sensitivities.

assay

≥97% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

solubility

water: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Broad-spectrum MMP and TACE substrate
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

The widely used MMP substrate FS-1 (Cat. No. 03-32-5032) is modified by an N-terminal lysine elongation to produce a broad-spectrum MMP and TACE substrate that displays improved water solubility and substrate sensitivities. Exhibits 2- to 9-fold higher specificity constant (kcat/Km) towards MMP-1, -8, -13, -14 when compared with FS-1 and ~2-fold higher kcat/Km towards TACE when compared with TACE Substrate II and III (Cat. Nos. 616402 and 616403, respectively). It has been used successfully in detecting T98G glioma cell surface-associated MMP activity and is shown to be resistant to proteolysis by human leukocyte elastase, trypsin, and ADAM-10.

Other Notes

Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH₂
Neumann, U., et al. 2004. Anal. Biochem.328, 166.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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