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444284

MMP-2/MMP-3 Inhibitor III, PD166793

Name: MMP-2/MMP-3 Inhibitor III, PD166793
Brand: MM

The MMP-2/MMP-3 Inhibitor III, PD166793, also referenced under CAS 199850-67-4, controls the biological activity of MMP-2/MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

MMP-2/MMP-3 Inhibitor III, PD166793, (S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₈BrNO₄S

CAS Number:

199850-67-4

Molecular Weight:

412.30

MDL number:

MFCD09038565

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (TLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Quality Segment

100

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 40 mg/mL, ethanol: 40 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(N[C@@H](C(C)C)C(=O)O)c1ccc(cc1)c2ccc(cc2)Br

InChI

1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1

InChI key

GJOCABIDMCKCEG-INIZCTEOSA-N

Description

General description

A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC₅₀ = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC₅₀ = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
MMP-2, -3, and -13

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 47, 12, and 8 nM, against MMP-2, -3, and -13, respectively

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Paolocci, N., et al. 2006. J. Pharm. Exp. Ther.317, 506.
Zhou, Y.P., et al. 2005. Diabetes54, 2612.
Peterson, J.T., et al. 2001. Circulation103, 2303.
Spinale, F.G., et al. 1999. Circ. Res.85, 364.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c