444288
MMP-2 Inhibitor III
The MMP-2 Inhibitor III, also referenced under CAS 704888-90-4, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
MMP-2 Inhibitor III, (2-((Isopropoxy)-(1,1ʹ-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide
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About This Item
Empirical Formula (Hill Notation):
C17H20N2O5S
CAS Number:
Molecular Weight:
364.42
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
methanol: 100 mg/mL, DMSO: 200 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(N(OC(C)C)CC(=O)NO)c1ccc(cc1)c2ccccc2
InChI
1S/C17H20N2O5S/c1-13(2)24-19(12-17(20)18-21)25(22,23)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13,21H,12H2,1-2H3,(H,18,20)
InChI key
PHGLPDURIUEELR-UHFFFAOYSA-N
General description
A cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn2+-binding site-targeting inhibitor of MMP-2 (IC50 = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC50 = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC50 >50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.
Biochem/physiol Actions
Target IC50: 12 nM against MMP-2
Cell permeable: yes
Primary Target
MMP-2
MMP-2
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Tuccinardi, T., et al. 2006. Bioorg. Med. Chem.14, 4260.
Rossello, A., et al. 2004. Bioorg. Med. Chem.12, 2441.
Rossello, A., et al. 2004. Bioorg. Med. Chem.12, 2441.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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