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Merck

444805

Membrane Traffic Inhibitor, A5

The Membrane Traffic Inhibitor, A5 controls the biological activity of adaptor complex AP-1.

Synonym(s):

Membrane Traffic Inhibitor, A5, 1-(4-(4-(E-2-Methyl-2-butenyl)piperazinyl)phenyl)ethanone, HCl, 5431942, A5

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About This Item

Empirical Formula (Hill Notation):
C17H24N2O · xHCl
Molecular Weight:
272.39 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200

Product Name

Membrane Traffic Inhibitor, A5, The Membrane Traffic Inhibitor, A5 controls the biological activity of adaptor complex AP-1.

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

pale yellow

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable piperazinyl compound that specifically blocks clathrin adaptor complex AP-1-dependent traffic between trans-Golgi network (TGN) and endosomes in budding yeast, while exhibiting little effects against other trafficking pathways involving TGN and endosomes. Inhibits growth of yeast cells lacking complementary GGA1/2 adaptor proteins (EC50 = 50 µM), but not wild-type or AP-1-deficient cells even at concentrations as high as 300 µM. A5 presumably acts at a stage after AP-1 membrane recruitment as evidenced by an enhanced AP-1 perinuclear localization upon A5 treatment of HeLa cells.

Other Notes

Duncan, M.C., et al. 2007. Proc. Natl. Acad. Sci. USA104, 6235.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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