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Merck

444938

MEK Inhibitor II - CAS 623163-52-0 - Calbiochem

The MEK Inhibitor II, also referenced under CAS 623163-52-0, controls the biological activity of MEK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

MEK Inhibitor II - CAS 623163-52-0 - Calbiochem, 2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone

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About This Item

Empirical Formula (Hill Notation):
C14H8ClNO4
CAS Number:
623163-52-0
Molecular Weight:
289.67
UNSPSC Code:
12352200

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Product Name

MEK Inhibitor II - CAS 623163-52-0 - Calbiochem, The MEK Inhibitor II, also referenced under CAS 623163-52-0, controls the biological activity of MEK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

Biochem/physiol Actions

Cell permeable: yes
Primary Target
MEK1
Product does not compete with ATP.
Reversible: no
Target IC50: 0.38 µM for MEK1

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

General description

A cell-permeable 1,4-naphthoquinone compound that acts as potent and selective inhibitor of MEK (IC50 = 0.38 µM for MEK1). It shows little effect on PKC and PKA, and inhibits Raf1 and ERK1 only at much higher concentrations (IC50 = 34.5 and 82.9 µM, respectively).
A cell-permeable, potent, and selective inhibitor of MEK (IC50 = 380 nM for MEK1). Exhibits negligible inhibitory effects on protein kinase C (PKC) and protein kinase A (PKA). Inhibits Raf1 and ERK1 only at much higher concentrations (IC50 = 34.5 µM and 82.9 µM, respectively).

Other Notes

Bakare, O., et al. 2003. Bioorg. Med. Chem.11, 3165.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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