444938
MEK Inhibitor II - CAS 623163-52-0 - Calbiochem
The MEK Inhibitor II, also referenced under CAS 623163-52-0, controls the biological activity of MEK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
MEK Inhibitor II - CAS 623163-52-0 - Calbiochem, 2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone
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About This Item
Empirical Formula (Hill Notation):
C14H8ClNO4
CAS Number:
Molecular Weight:
289.67
UNSPSC Code:
12352200
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable 1,4-naphthoquinone compound that acts as potent and selective inhibitor of MEK (IC50 = 0.38 µM for MEK1). It shows little effect on PKC and PKA, and inhibits Raf1 and ERK1 only at much higher concentrations (IC50 = 34.5 and 82.9 µM, respectively).
A cell-permeable, potent, and selective inhibitor of MEK (IC50 = 380 nM for MEK1). Exhibits negligible inhibitory effects on protein kinase C (PKC) and protein kinase A (PKA). Inhibits Raf1 and ERK1 only at much higher concentrations (IC50 = 34.5 µM and 82.9 µM, respectively).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
MEK1
MEK1
Product does not compete with ATP.
Reversible: no
Target IC50: 0.38 µM for MEK1
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bakare, O., et al. 2003. Bioorg. Med. Chem.11, 3165.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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