c-Met Kinase Inhibitor III

Name: c-Met Kinase Inhibitor III
Brand: MM

The c-Met Kinase Inhibitor III controls the biological activity of c-Met.

Synonym(s):

c-Met Kinase Inhibitor III, 2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₁₇Cl₂FN₂O₂

Molecular Weight:

419.28

UNSPSC Code:

12352200

Product Name

c-Met Kinase Inhibitor III, The c-Met Kinase Inhibitor III controls the biological activity of c-Met.

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

A 6-Benzyloxyquinoline derivative which acts as an ATP-competitive inhibitor against c-Met (IC₅₀ = 9.3 nM), with more than 20 fold selectivity against a panel of 19 receptor tyrosine kinases and 8 serine/threonine kinases, in enzymatic assays. Also exhibits MKN45 cell growth inhibition (IC₅₀ = 93 nM) and displays HDG-dependent anti-proliferative activity (IC₅₀ = 300 nM) in HUVEC cultures, in vitro.

Other Notes

Nishii, H., et al. 2009. Bioorg. Med. Chem. Lett.20, 1405.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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