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Merck

474705

Mevastatin, Sodium Salt

Carboxylate form of Mevastatin that is active in whole cells and in cell-free assays.

Synonym(s):

Mevastatin, Sodium Salt

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About This Item

Empirical Formula (Hill Notation):
C23H35O6 · Na
Molecular Weight:
430.51
NACRES:
NA.77
UNSPSC Code:
51111800

Product Name

Mevastatin, Sodium Salt, Carboxylate form of Mevastatin that is active in whole cells and in cell-free assays.

color

white

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

ethanol: 20 mg/mL
DMSO: 30 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
HMG-CoA reductase
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays.
Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays. Mevastatin is an antibiotic that acts as a potent inhibitor of HMG-CoA reductase. Suppresses Ras farnesylation and inhibits myoblast fusion. Causes cell cycle arrest in late G1 phase. Mevastatin may also induce bone morphogenic protein-2 (BMP-2).

Other Notes

Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun.271, 88.
Endo, A. 1992. J. Lipid Res.33, 1569.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mouhannad Malek et al.
Nature communications, 12(1), 2673-2673 (2021-05-13)
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. Here we reveal a

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