475250
4-{[3ʹ,4ʹ-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline
Synonym(s):
4-{[3ʹ,4ʹ-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline
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About This Item
Empirical Formula (Hill Notation):
C17H15N3O3
CAS Number:
Molecular Weight:
309.32
UNSPSC Code:
12352200
assay
≥98% (HPLC)
Quality Level
form
solid
potency
230 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
Potent and specific inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50 = 230 nM). Elevates the intracellular cGMP level without causing a change in the cAMP level in isolated porcine coronary arteries. Has no effect on other PDE isoenzymes.
Biochem/physiol Actions
Primary Target
CGMP-PDEV
CGMP-PDEV
Other Notes
Takase, Y., et al. 1994. J. Med. Chem.37, 2106.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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