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Merck

475843

Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem

Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci.

Synonym(s):

Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem, 7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl

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About This Item

Empirical Formula (Hill Notation):
C23H27N3O7 · xHCl
CAS Number:
13614-98-7
Molecular Weight:
457.48 (free base basis)
UNSPSC Code:
12352200
MDL number:
MFCD00083669

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Product Name

Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem, Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci.

InChI

1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,32-33H,7-8,24H2,1-4H3;1H/b22-16-;/t9-,11-,17-,23-;/m0./s1

InChI key

KDLQIOPKJDNQIM-WUURTAMISA-N

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

dark yellow

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
Metalloproteinase (MMP)
Product does not compete with ATP.
Reversible: no
Target IC50: 290 µM against MMP-3
Target Ki: 13.4 nM against PARP-1

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

General description

Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.
This product has been discontinued.

Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 M) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.

Other Notes

Conrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA103, 9685.
Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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