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Merck

475847

MIF Antagonist IV, RDR 03785

The MIF Antagonist IV, RDR 03785 controls the biological activity of MIF. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

MIF Antagonist IV, RDR 03785, Macrophage Migration Inhibitory Factor Antagonist IV, 6-(Morpholino(4-(trifluoromethyl)phenyl)methyl)-1,3-benzodioxol-5-ol

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About This Item

Empirical Formula (Hill Notation):
C19H18F3NO4
CAS Number:
289657-30-3
Molecular Weight:
381.35
UNSPSC Code:
12352200
PubChem Substance ID:
2725942
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

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SMILES string

C1COCCN1C(C2=CC=C(C=C2)C(F)(F)F)C3=CC4=C(C=C3O)OCO4

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

cream

solubility

DMSO: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

General description

A cell-permeable morpholino-benzodioxol compound that inhibits MIF tautomerase activity (Ki and IC50 = 0.57 and 2.4 µM, respectively) via direct non-covalent MIF interaction (KD = 24.5 µM). RDR 03758 at 10 µM is shown to completely neutralize the overriding effect of 100 ng/ml MIF on the inhibition of LPS-stimulated TNF production by dexamethasone (Cat. No. 265005 ) in RAW 264.7 marcophage cultures.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Ouertatani-Sakouhi, H., et al. 2010. J. Biol. Chem.285, 26581.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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