475851
Mitaplatin
Synonym(s):
Mitaplatin, c,c,t-[Pt(NH₃)₂Cl₂(O₂CCHCl₂)₂]
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About This Item
Empirical Formula (Hill Notation):
C10H22Cl6N4O6Pt
Molecular Weight:
702.10
UNSPSC Code:
12352200
Assay
≥95% (NMR)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white to cream
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable Pt(IV) compound that, upon reduction inside cells, yields two molecules of the PDK (pyruvate dehydrogenase kinase) inhibitor DCA/dichloroacetate and one molecule of the apoptosis inducer Cisplatin (Cat. No. 232120). While the dual prodrug nature of Mitaplatin is shown to result in increased cell killing than Cisplatin in the human ovarian carcinoma A2780/CP70 cultures (IC50 = 3.34 and 6.0, respectively), the anticancer potency of Mitaplatin is often weaker than Cisplatin in other cancer cells tested, presumably due to insufficient prodrug reduction in these cells.
Note: Carboplatin, Cisplatin, and other platinum drugs are reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Solubilization with DMSO prior to culture treatment is not recommended.
Note: Carboplatin, Cisplatin, and other platinum drugs are reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Solubilization with DMSO prior to culture treatment is not recommended.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Use only fresh DMSO for reconstitution.
Other Notes
Hall, M.D., et al. 2014. Cancer Res. In press.
Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA106, 22199.
Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA106, 22199.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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