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475863

MK2a Inhibitor

The MK2a Inhibitor, also referenced under CAS 41179-33-3, controls the biological activity of MK2a. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

MK2a Inhibitor, Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2ʹ-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1, MAPKAPK2a Inhibitor

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About This Item

Empirical Formula (Hill Notation):
C22H20FNO2
CAS Number:
41179-33-3
Molecular Weight:
349.40
MDL number:
MFCD08703098
UNSPSC Code:
12352202
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
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Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 5 mg/mL, ethanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1c(cccc1)c2ccc(cc2)CCCC(=O)Nc3ccc(cc3)O

InChI

1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26)

InChI key

ODYAQBDIXCVKAE-UHFFFAOYSA-N

General description

A non-ATP-competitive, reversible, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (Kiapp = 330 nM). Does not inhibit p38α-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.
A reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; Kiapp = 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.

Biochem/physiol Actions

Cell permeable: no
Kiapp = 330 nM against mitogen-activated protein kinase-activated protein kinase 2a (MK2a)
Primary Target
Mk2α
Product does not compete with ATP.
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Davidson, W., et al. 2004. Biochemistry43, 11658.
Lukas, S.M., et al. 2004. Biochemistry43, 9950.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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