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475878

(+)-MK 801 Maleate

Name: (+)-MK 801 Maleate
Brand: MM

A highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca²⁺ flux.

Synonym(s):

(+)-MK 801 Maleate, (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₅N · xC₄H₄O₄

CAS Number:

77086-22-7

Molecular Weight:

221.30 (free base basis)

UNSPSC Code:

12352200

MDL number:

MFCD00082465

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white

solubility

water: 3 mg/mL, ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1

InChI key

QLTXKCWMEZIHBJ-PJGJYSAQSA-N

Description

General description

A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca²⁺ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca²⁺ entry induced seizures.

A highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca²⁺ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca²⁺ entry induced seizures.

Biochem/physiol Actions

Cell permeable: no

Primary Target
NMDA receptor

Reversible: no

Preparation Note

Following reconstitution in water refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Aqueous stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

Stock solutions in water may require warming and vigorous stirring to achieve complete solubilization.

Other Notes

Ikonomidou, C., et al. 1999. Science 283, 70.
DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c