475880
ML-7 Hydrochloride
>98% (TLC), protein kinase A and C inhibitor, solid
Synonym(s):
ML-7, Hydrochloride, 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
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About This Item
Empirical Formula (Hill Notation):
C15H17IN2O2S · xHCl
CAS Number:
Molecular Weight:
416.28 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
>98% (TLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Product Name
ML-7, Hydrochloride, A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).
Quality Segment
assay
>98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
50% ethanol: 4.5 mg/mL, DMSO: 4.5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Ic1c2c(c(ccc2)[S](=O)(=O)N3CCNCCC3)ccc1
InChI
1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
InChI key
GEHJIACZUFWBTK-UHFFFAOYSA-N
General description
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM)and protein kinase C (Ki = 42 µM) at much higher concentrations.
Biochem/physiol Actions
Primary Target
Myosin light chain kinase (Mlck)
Myosin light chain kinase (Mlck)
Product competes with ATP.
Reversible: yes
Target Ki: 300 nM against myosin light chain kinase
Cell permeable: yes
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Further dilute with aqueous buffer just prior to use.
Other Notes
Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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