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Merck

475895

Monensin, Sodium Salt, High Purity

Polyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane.

Synonym(s):

Monensin, Sodium Salt, High Purity

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About This Item

Empirical Formula (Hill Notation):
C36H61O11 · Na
CAS Number:
22373-78-0
Molecular Weight:
692.85
UNSPSC Code:
12352200
MDL number:
MFCD00077826

Key Documents

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Product Name

Monensin, Sodium Salt, High Purity, Polyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane.

InChI

1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-;/m0./s1

InChI key

XOIQMTLWECTKJL-FBZUZRIGSA-M

assay

≥97% (by Assay)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white to beige

solubility

chloroform: soluble
ethanol: soluble
methanol: soluble

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Functions as a Na+ ionophore

Disclaimer

Toxicity: Highly Toxic (H)

General description

Polyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Inabayashi, M., et al. 1995. Biochemistry34, 3455.
Mendez, A.J. 1995. J. Biol. Chem.270, 5891.
Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta1213, 193.
Griffin, T., et al. 1993. J. Natl. Cancer Inst.85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res.53, 658.
Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta1104, 123.
Kok, J.W. 1992. J. Cell. Sci.103, 1139.
Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol.44, 1395.

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Unstable in acidic solutions.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2

target_organs

Heart,muscle

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Bingqing Zheng et al.
International journal of molecular sciences, 22(14) (2021-07-25)
NK cells play crucial roles in defending against persistent HBV. However, NK cells present dysfunction in chronic hepatitis B virus (CHB) infection, and the associated mechanism is still not fully understood. Except for the regulatory receptors, NK cells could also

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