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Merck

475984

MyoVin-1

A pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V.

Synonym(s):

MyoVin-1, Myosin V Inhibitor 1

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About This Item

Empirical Formula (Hill Notation):
C29H26N6O3S
CAS Number:
1259177-59-7
Molecular Weight:
538.62
UNSPSC Code:
12352200
NACRES:
NA.51
MDL number:
MFCD32009180

Key Documents

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Product Name

MyoVin-1, A pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V.

InChI key

JTMFLTNSCRPRHU-UHFFFAOYSA-N

SMILES string

O=C(C1=CC=CC(SCC2=CC=CC(NC3=NC(NN=C4C5=CC=C(N6CCOCC6)C=C5)=C4C=N3)=C2)=C1)O

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Disclaimer

Toxicity: Standard Handling (A)

General description

A pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V (Ki = 6.3 and 5.5 µM by single- and double-headed myosin V). Displays excellent selectivity over myosin II and myosin IV (<10% inhibition at 50 µM) and only minimally inhibits the kinase activity of Cdk1/B, CHK1, Plk1, Abl, ERK2, CKII and Aurora-B (<10% inhibition at 100 µM).

Other Notes

Islam, K., et al. 2010. Angew. Chem. Int. Ed.49, 8484.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Ana Rita Costa et al.
eLife, 9 (2020-03-21)
Neurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain- and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that controls axonal expansion

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