480026
NBD-Binding Peptide II, Cell Permeable, CTP-NBD
A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50~ 50 µM in HCT116 cells).
Synonym(s):
NBD-Binding Peptide II, Cell Permeable, CTP-NBD, NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD
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About This Item
Empirical Formula (Hill Notation):
C123H197N47O32
Molecular Weight:
2846.18
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 µM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (Cat. No. 480025 ).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
NEMO-binding peptide
NEMO-binding peptide
Reversible: yes
Packaging
Packaged under inert gas
Yes
Other Notes
Ac-YGRRARRRARRTALDWSWLQTE-NH₂
Hong, S., et al. 2012. Mol. Pharm.9, 1310.
Kim, D., et al. 2006. Exp. Cell Res.312, 1277.
Kim, D., et al. 2006. Exp. Cell Res.312, 1277.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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