Skip to Content
Merck

480030

NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control

A cell-permeable Antennapedia-NBD mutated fusion peptide analog of NEMO-Binding Domain Binding Peptide that serves as a negative control.

Synonym(s):

NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control, DRQIKIWFQNRRMKWKK-TALDASALQTE, NBD-Binding Peptide, Cell-Permeable, Negative Control

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C154H249N47O42S
Molecular Weight:
3462.98
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic)

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

off-white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

General description

A cell-permeable Antennapedia-NBD mutated (Trp739 and Trp741 replaced with Ala) fusion peptide analog of NEMO-Binding Domain Binding Peptide (Cat. No. 480025) that serves as a negative control. Shown to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.
A cell-permeable, Antennapedia-NBD mutated (Trp739 → Ala and Trp741 → Ala) fusion peptide analog of NEMO-Binding Domain Binding peptide (Cat. No. 480025) that serves as a negative control. Reported to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun or DNA binding of the transcription factor Oct-1.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Negative control defective in binding to NEMO
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Other Notes

H₂N-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Ala-Ser-Ala-Leu-Gln-Thr-Glu-OH
Jimi, E., et al. 2004. Nat. Med., 10, 617.
May, M.J., et al. 2000. Science289, 1550.
This peptide will precipitate when added to tissue culture medium even at 100 µM concentrations; however, sufficient material will stay in solution to permeate cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service