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Merck

480748

Neuronal Differentiation Inducer, Isobavachin

A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM.

Synonym(s):

Neuronal Differentiation Inducer, Isobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one, Isobavachin, Isobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one

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About This Item

Empirical Formula (Hill Notation):
C20H20O4
CAS Number:
31524-62-6
Molecular Weight:
324.37
UNSPSC Code:
12352200

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Product Name

Neuronal Differentiation Inducer, Isobavachin, A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM.

SMILES string

OC1=CC=C(C(CC(C2=CC=C(O)C=C2)O3)=O)C3=C1CC=C(C)C

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

drug control

Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 100 mg/mL, clear, yellow

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM. It is shown to elicit the down-regulation of p38 and JNK phosphorylation, and the up-regulation of ERK phosphorylation. Co-treatment with GGTI-298 (1000 nM), a Geranylgeranyltransferase I Inhibitor (Cat. No. 345883) selectively abolishes the IBA- but not Retinoic Acid-induced neuronal differentiation, which suggests that the differentiation inducing effect may involve protein prenylation.

Other Notes

Wang, D.Y., et al. 2011. Acta Pharmacol Sin32, 425.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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