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Merck

484100

5-Nitro-2-(3-phenylpropylamino)benzoic Acid

Potent Cl⁻ channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method.

Synonym(s):

5-Nitro-2-(3-phenylpropylamino)benzoic Acid, NPPB, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II, ANO Blocker II, Anoctamin Blocker II

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About This Item

Empirical Formula (Hill Notation):
C16H16N2O4
CAS Number:
107254-86-4
Molecular Weight:
300.31
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD00153851

Key Documents

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Product Name

5-Nitro-2-(3-phenylpropylamino)benzoic Acid, Potent Cl⁻ channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method.

SMILES string

[N+](=O)([O-])c1cc(c(cc1)NCCCc2ccccc2)C(=O)O

InChI

1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)

InChI key

WBSMIPAMAXNXFS-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

yellow

solubility

DMSO: 5 mg/mL
warm ethanol: soluble

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
Cl⁻ channel blocker
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM-100 µM as Cl-channel blocker

Disclaimer

Toxicity: Standard Handling (A)

General description

Potent Cl– channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC50 = 8 µM).
Potent Cl- channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC50 = 8 µM).

Other Notes

Illek, B., et al. 1992. Am. J. Physiol.263, C644.
Kirk, K., et al. 1992. J. Biol. Chem.267, 23475.
Breuer, W., et al. 1989. Biochem. Biophys. Res. Commun.163, 398.
Wangermann, P., et al. 1986. Pflugers Arch.407, S128.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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