487955
NOC-12
A nitric oxide (NO) donor similar to NOC-5 and NOC-7 but with a much longer half-life of NO release.
Synonym(s):
NOC-12, N-Ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino)ethanamine
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About This Item
Empirical Formula (Hill Notation):
C6H16N4O2
CAS Number:
Molecular Weight:
176.22
UNSPSC Code:
12352200
MDL number:
Assay:
≥90% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
0.1 M NaOH: soluble, water: soluble
shipped in
ambient
storage temp.
−20°C
InChI
1S/C6H16N4O2/c1-3-7-5-6-9(4-2)10(12)8-11/h7,11H,3-6H2,1-2H3/b10-8-
InChI key
DPKCLDSTXVCYSN-NTMALXAHSA-N
General description
A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950) and NOC-7 (Cat. No. 487952) but with a much longer half-life of NO release. Half-life (t½) in PBS, pH 7.4 is 327 minutes at 22°C. Inhibits the proliferation of arterial smooth muscle cells in a dose-dependent manner. Relatively stable in alkaline solution (pH ≥10.0).
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: no
Other Notes
Ambalavanan, N., et al. 1999. Biol. Neonate76, 291.
Hrabie, J.A., et al. 1993. J. Org. Chem.58, 1472.
Hrabie, J.A., et al. 1993. J. Org. Chem.58, 1472.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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