495621
Olomoucine II
A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B.
Synonym(s):
Olomoucine II, 6-(2-Hydroxybenzylamino)-2-((1R)-(hydroxymethyl)propyl)amino)-9-isopropylpurine
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About This Item
Empirical Formula (Hill Notation):
C19H26N6O2
CAS Number:
Molecular Weight:
370.45
UNSPSC Code:
12352200
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
colorless
solubility
DMSO: 1 mg/mL, ethanol: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C19H26N6O2/c1-4-14(10-26)22-19-23-17(20-9-13-7-5-6-8-15(13)27)16-18(24-19)25(11-21-16)12(2)3/h5-8,11-12,14,26-27H,4,9-10H2,1-3H3,(H2,20,22,23,24)
InChI key
NDUVSANREQEDRE-UHFFFAOYSA-N
General description
A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC50 of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 µM) and Olomoucine (Cat. No. 495620; IC50 = 7.0 µM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 µM, 5.3 µM, 6.3 µM, 6.3 µM and 11.1 µM for CEM, MCF7, HOS, G631 and K562, respectively).
A cell-permeable, potent, reversible, and ATP-competitive inhibitor of Cdk1/cyclin B (IC50 = 20 nM) that displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 µM), and Olomoucine (Cat. No. 495620; IC50 = 7.0 µM). Also exhibits greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 µM, 5.3 µM, 6.3 µM, 6.3 µM, and 11.1 µM for CEM, MCF7, HOS, G631, and K562, respectively).
Biochem/physiol Actions
Reversible: yes
Target IC50: 20 nM against Cdk1/B
Cell permeable: yes
Primary Target
Cdk1/B
Cdk1/B
Product competes with ATP.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Krystof, V., et al. 2002. Bioorg. Med. Chem. Lett.12, 3283.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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