495624
Olomoucine
InSolution, ≥98%, potent and selective inhibitor of p34cdc2/cyclin B and related kinases
Synonym(s):
InSolution Olomoucine
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About This Item
Empirical Formula (Hill Notation):
C15H18N6O
Molecular Weight:
298.34
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
2-8°C
General description
A purine derivative that acts as a potent and selective inhibitor of p34cdc2/cyclin B (IC50 = 7 µM) and related kinases, including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44MAPK (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D1 (IC50 >1 mM) and p40cdk6/cyclin D3 (IC50 >250 µM). Does not significantly affect the activity of other protein kinases even at 1 mM concentrations. Known to inhibit DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Also used to synchronize cells in G1.
Biochem/physiol Actions
Cell permeable: no
Primary Target
p34cdk1/cyclin B
p34cdk1/cyclin B
Product competes with ATP.
Reversible: yes
Target IC50: 100 nM-100 µM against p34cdk1/cyclin B
Packaging
Packaged under inert gas
Physical form
A 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495620) in DMSO.
Preparation Note
Following initial use, aliquot and refrigerate (4°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
Certificates of Analysis (COA)
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