form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Major hubs involved in TLR signaling cascade
Major hubs involved in TLR signaling cascade
Disclaimer
Toxicity: Irritant (B)
General description
A panel containing 16 potent, selective and cell-permeable inhibitors that is useful for the study of TLR signaling: 1 mg of TIRAP Inhibitor Peptide, Cell-Permeable (>Cat. No. 613570), 10 mg of IL-1R Antagonist (>Cat. No. 407616), 5 mg of Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor (Cat. No. 407601), 1 mg of (5Z)-7-Oxozeaenol, Curvularia sp. (Cat. No. 499610), 10 mg of BX-795 (Cat. No. 204001), 5 mg of NBD-Binding Peptide II, Cell Permeable, CTP-NBD (Cat. No. 480026), 25 mg of Cdc42/Rac1 GTPase Inhibitor, ML141 (Cat. No. 217708), 5 mg of PKR Inhibitor (Cat. No. 527450), 5 mg of LY294002 (Cat. No. 440202), 5 mg of U0126 (Cat. No. 662005), 1 mg of IKK Inhibitor VII (Cat. No. 401486), 10 mg of BAY 11-7082 (Cat. No. 196870), 1 mg of SB 203580 (Cat. No. 559389), 5 mg of SP600125 (Cat. No. 420119), 10 mg of STAT3 Inhibitor III, WP1066 (Cat. No. 573097), and 10 mg of MG-132 (Cat. No. 474787). Also provided with 15 ml of anhydrous DMSO (Cat. No. KP31817).
Other Notes
Aksoy, E., et al. 2012. Nat. Immunol.13, 1045.
Kondo, T., et al. 2012. Trends Immunol.33, 449.
Kawai, T. and Akira, S., 2010. Nat. Immunol.11, 373.
Kong, L. and Ge, B.X., 2008. Cell Res.18, 745.
Gilliet, M., et al. 2008. Nat. Rev. Immunol.8, 594.
Verstrepen, L., et al. 2008. Cell. Mol. Life Sci.65, 2964.
Wong, C.K., et al. 2007. Am. J. Respir. Cell Mol. Biol.37, 85.
Kawai, T. and Akira, S., 2007. Trends Mol. Med.13, 460.
Kondo, T., et al. 2012. Trends Immunol.33, 449.
Kawai, T. and Akira, S., 2010. Nat. Immunol.11, 373.
Kong, L. and Ge, B.X., 2008. Cell Res.18, 745.
Gilliet, M., et al. 2008. Nat. Rev. Immunol.8, 594.
Verstrepen, L., et al. 2008. Cell. Mol. Life Sci.65, 2964.
Wong, C.K., et al. 2007. Am. J. Respir. Cell Mol. Biol.37, 85.
Kawai, T. and Akira, S., 2007. Trends Mol. Med.13, 460.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C) each inhibitor. Each inhibitor solution is stable for up to 3 months at -20°C.
Please refer to information provided on the CD for reconstitution information of individual inhibitors.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - (Dimethylsulfoxide)
flash_point_c
87 °C - (Dimethylsulfoxide)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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