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Merck

5.00670

FATP2 Inhibitor, CB-2

Synonym(s):

FATP2 Inhibitor, CB-2, (5E)-5-((3-bromo-4-hydroxy-5-methoxyphenyl)methylene)-3-(3-chlorophenyl)-2-thioxothiazolidin-4-one, CB2, Fatty Acid Transport Protein 2 Inhibitor

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About This Item

Empirical Formula (Hill Notation):
C17H11BrClNO3S2
Molecular Weight:
456.76
NACRES:
NA.77
UNSPSC Code:
41106300

Key Documents

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assay

≥99% (HPLC)

form

solid

potency

8 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

Quality Level

100

General description

A cell permeable thioxothiazolindine compound that reversibly inhibits FATP2-mediated long chain fatty acid uptake in Caco-2 and HepG2, but not non-FATP2-expressing 3T3-L1 adipocytes, cultures (IC50 = 3.99, 7.55, and 231.1 µM, respectively), while exhibiting much reduced potency toward cellular Acsl (acyl-CoA synthetase) activity (IC50 = 50 µM). Shown not to affect Caco-2 viability, membrane permeability, or glucose transport.

Biochem/physiol Actions

Cell permeable: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sandoval, A., et al. 2010. Biochem. Pharmacol.79, 99.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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