5.00671
HDAC Inhibitor XVII
Synonym(s):
HDAC Inhibitor XVII, (E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII
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About This Item
Empirical Formula (Hill Notation):
C22H19NO3
CAS Number:
Molecular Weight:
345.39
UNSPSC Code:
12352200
Assay:
≥99% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Segment
form
powder
potency
27 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
light beige
solubility
DMSO: 100 mg/mL
storage temp.
2-8°C
General description
A cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27 nM), displaying much reduced potency against HDAC1/3 (IC50 = 3.0 µM) and little or no activity toward HDAC2/4/6/10/11 (IC50 >20 µM) or total HDAC activity in HeLa nuclear extract (IC50 >10 µM). Reported to exhibit antiproliferative activity toward human lung cancer cells CL1-5, H1299, and A549 (IC50 = 7.0, 7.2, and 7.9 µM, respectively), while being much less toxic to low HDAC8-expressing CL1-1 (IC50 >10 µM) or normal human lung IMR-90 (73% inhibition at 40 µM) cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
HDAC8 selective
HDAC8 selective
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Huang, W. J., et al. 2012. ChemMedChem.7, 1815.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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