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5.04120

Reboxetine Mesylate

Synonym(s):

Reboxetine Mesylate, (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine methanesulfonate, Edronax, Vestra

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About This Item

Empirical Formula (Hill Notation):
C19H23NO3 · xCH4O3S
CAS Number:
98769-84-7
Molecular Weight:
313.39 (free base basis)
MDL number:
MFCD18711354
UNSPSC Code:
12352200
NACRES:
NA.77
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assay

≥99% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

color

white

solubility

water: 20 mg/mL

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(O)C.N1C[C@@H](OCC1)[C@H](Oc3c(cccc3)OCC)c2ccccc2

InChI

1S/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m1./s1

InChI key

CGTZMJIMMUNLQD-STYNFMPRSA-N

General description

A potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and >10000 nM for rat NET, SERT and DAT, respectively). Displays >1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.

Biochem/physiol Actions

Primary Target
Noradrenalin transporter
Target Ki: 1.1, 129 and >10000 nM for rat NET, SERT and DAT respectively

Preparation Note

Following reconstitution, aliquot and freeze 9-20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sacchetti, G., et al. 1999. Br. J. Pharmacol.128, 1332.

Wong, E., et al. 2000. Biol. Psychiatry.47, 818.
Millan, M., et al. 2001. J. Pharmacol. Exp. Ther.298,565.
Owen, J., et al. 2003 Neurosci. Lett.348, 171.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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