Key Documents

View All Documentation

5.04345

BX471

Name: BX471
Brand: MM

Synonym(s):

BX471, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₄ClFN₄O₃

CAS Number:

217645-70-0

Molecular Weight:

434.89

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, protect from light

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

assay

≥98% (HPLC)

Quality Level

100

form

powder

potency

1-5 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white to beige

solubility

DMSO: ≥25 mg/mL

storage temp.

2-8°C

InChI

1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1

InChI key

XQYASZNUFDVMFH-CQSZACIVSA-N

Description

General description

An orally active, selective antagonist for chemokine receptor 1 (CCR-1) (K_i = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.

Biochem/physiol Actions

Primary Target
CCR1

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shahlaei, M., et al. 2011. J. Chemical Information and Modeling.51, 2717.

Reuss, R., et al. 2010. Mult Scler.16, 366.

Gladue, R., et al. 2010. Curr Top Med Chem10, 1268.

Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol.68, 435.

Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry.5, 791.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Still not finding the right product?

Explore all of our products under BX471

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_c

Not applicable

flash_point_f