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Merck

5.04361

INCB 3284 Dimesylate

Synonym(s):

INCB 3284 Dimesylate, N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate, INCB 3284, INCB3284

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About This Item

Empirical Formula (Hill Notation):
C26H31F3N4O4 · 2CH4O3
CAS Number:
887401-93-6
Molecular Weight:
648.63
UNSPSC Code:
12352200
Assay:
≥98% (TLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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InChI key

PNPNUHKICDECDH-SEBNIYPMSA-N

InChI

1S/C26H31F3N4O4.2CH4O3S/c1-37-23-6-5-19(14-30-23)25(36)10-7-21(8-11-25)33-12-9-20(16-33)32-22(34)15-31-24(35)17-3-2-4-18(13-17)26(27,28)29;2*1-5(2,3)4/h2-6,13-14,20-21,36H,7-12,15-16H2,1H3,(H,31,35)(H,32,34);2*1H3,(H,2,3,4)/t20-,21?,25?;;/m1../s1

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 12 mg/mL

storage temp.

−20°C

Quality Level

100

General description

A potent and highly selective human CCR2 (hCCR2) antagonist (IC50 = 3.7 nM, 4.7 nM, and 84 nM for monocyte chemoattractant protein-1 binding to hCCR2, chemotaxis activity, inhibition of the hERG potassium current, respectively).

Biochem/physiol Actions

Primary Target
human CCR2 (hCCR2)
Target IC50: 3.7 nM, 4.7 nM, and 84 nM for different assays.

Preparation Note

Following reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Xia, M., et al. 2009. Expert Opinion on Therapeutic Patents.19, 295.

Xue, C., et al. 2011. ACS Med. Chem. Lett.2, 450.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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