Skip to Content
Merck

Key Documents

5.04373

Sigma-Aldrich

Vicriviroc Malate - CAS 541503-81-5 - Calbiochem

Synonym(s):

Vicriviroc Malate - CAS 541503-81-5 - Calbiochem, (4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690

Sign Into View Organizational & Contract Pricing

Select a Size

All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C28H38F3N5O2 · xC4H6O5
CAS Number:
541503-81-5
Molecular Weight:
533.63
UNSPSC Code:
12352200

Assay

≥90% (HPLC)

Quality Level

100

form

powder

potency

0.91 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

beige

solubility

DMSO: soluble

storage temp.

−20°C

General description

A potent, noncompetitive allosteric antagonist for CCR5 (IC50 = 0.91 nM). An effective entry inhibitor of HIV-1. Inhibits the initial stages of the virus life cycle. Efects can be resisted by mutation in the gp120 V3 region of HIV-1 both in vitro and in vivo.

Biochem/physiol Actions

Primary Target
CCR5

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Berro, R., et al. 2012. Virology427, 158.

Velasco-Velzquez, M, et al. 2012. Cancer Res.72, 3839.
Zembruski, N., et al. 2011. J. Antimicrob. Chemother.66, 802.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service