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Merck

5.04373

Vicriviroc Malate - CAS 541503-81-5 - Calbiochem

Synonym(s):

Vicriviroc Malate - CAS 541503-81-5 - Calbiochem, (4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690

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About This Item

Empirical Formula (Hill Notation):
C28H38F3N5O2 · xC4H6O5
CAS Number:
541503-81-5
Molecular Weight:
533.63
UNSPSC Code:
12352200

Assay

≥90% (HPLC)

Quality Level

100

form

powder

potency

0.91 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

beige

solubility

DMSO: soluble

storage temp.

−20°C

General description

A potent, noncompetitive allosteric antagonist for CCR5 (IC50 = 0.91 nM). An effective entry inhibitor of HIV-1. Inhibits the initial stages of the virus life cycle. Efects can be resisted by mutation in the gp120 V3 region of HIV-1 both in vitro and in vivo.

Biochem/physiol Actions

Primary Target
CCR5

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Berro, R., et al. 2012. Virology427, 158.

Velasco-Velzquez, M, et al. 2012. Cancer Res.72, 3839.
Zembruski, N., et al. 2011. J. Antimicrob. Chemother.66, 802.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Certificates of Analysis (COA)

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