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COA/COQ

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5.04463

BINA

Name: BINA
Brand: MM

Synonym(s):

BINA, Biphenyl-indanone A

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₃₀O₄

CAS Number:

866823-73-6

Molecular Weight:

454.56

MDL number:

MFCD19440914

UNSPSC Code:

12352200

Assay

≥98% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 18 mg/mL

storage temp.

2-8°C

InChI

1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33)

InChI key

KMKBEESNZAPKMP-UHFFFAOYSA-N

General description

A selective positive allosteric modulator for mGlu receptor subtype 2 (EC₅₀ = 33.2 nM in CHO cells expressing human mGlu₂). No effect on other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.

Biochem/physiol Actions

Primary Target
mGlu₂

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bonnefous, C., et al. 2005. Bioorg. Med. Chem. Lett.15, 4354.
Galici, R., et al. 2006. J. Pharmacol. Exp. Ther.318, 173.
Benneyworth, M., et al. 2007. Mol. Pharmacol.72, 477.
Sheffler, D., et al. 2011. ACS Chem. Neurosci.2, 382.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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