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Merck

5.04596

TCN-201

Synonym(s):

TCN-201, 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide, NMDA Antagonist X

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About This Item

Empirical Formula (Hill Notation):
C21H17ClFN3O4S
CAS Number:
852918-02-6
Molecular Weight:
461.89
UNSPSC Code:
12352200
MDL number:
MFCD06683895
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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InChI

1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)

InChI key

FYIBXBFDXNPBSF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 5 mg/mL

storage temp.

2-8°C

Quality Level

100

General description

A negative allosteric modulator selective for NR2A containing NMDA receptors (pIC50 = 6.8 and <4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.

Biochem/physiol Actions

Primary Target
NMDA receptors

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bettini. E., et al. 2010. J. Pharm. Exp. Ther.335, 644.
Shin, A., et al. 2011. Br. J. Pharmacol.166, 1002.
Edman, S., et al. 2012. Neuropharmacology63, 441.
Hansen, K., et al. 2012. J. Neurosci.32, 6197.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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