5.04599
ML243
Synonym(s):
ML243, Cancer Stem Cell Inhibitor, ML243, ( E)-N-(4,5-Dihydrothiazol-2-yl)-3-(4-ethylphenyl)acrylamide, (2 E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)prop-2-enamide
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About This Item
Empirical Formula (Hill Notation):
C14H16N2OS
CAS Number:
Molecular Weight:
260.35
UNSPSC Code:
12352200
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
General description
A cell-permeable, biologically stable, 4-ethyl substituted cinnamide analog that selectively exerts an inhibitory effect on breast cancer stem-like cells (EC50 = 2 µM for epithelial-to-mesenchymal transition; HMLE_shEcad). Exhibits ~32-fold greater selectivity over isogenic control cells (EC50 = 64 µM; HMLE cell line expressing shRNA against eGFPcells; HMLE_sh_eGFP). Displays desirable aqueous solubility (~11.5 µM in PBS, pH 7.4) and excellent stability in human plasma and in glutathione solution. Shown to block the binding to a radio-labeled ligand to the Adenosine A2A Receptor (IC50 = 10 µM), but does not affect 68 other targets studied.
Biochem/physiol Actions
Cell permeable: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Use only fresh DMSO for reconstitution.
Other Notes
Germain, A.R., et al. 2013. Bioorg. Med. Chem. Lett.23, 1834.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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