5.04637
(S)-MCPG
동의어(들):
(S)-MCPG, (S)-α-Methyl-4-carboxyphenylglycine, Group I/II mGlu Antagonist, (S)-MCPG
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H11NO4
CAS 번호:
Molecular Weight:
209.20
UNSPSC Code:
12352200
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mM, H2O: 10 mM
storage temp.
2-8°C
InChI
1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/p-1/t10-/m0/s1
InChI key
DNCAZYRLRMTVSF-JTQLQIEISA-M
General description
A non-selective antagonist for group I/II mGlu receptors (minimal values of IC50 reported = 40 and 15 µM for mGlu1 and mGlu2, respectively). Often used as an agent to differentiate excitatory neurotransmissions mediated by glutamate from other neurotransmitters (i.e. dopamine, acetylcholine, and GABA in early brain development). A common component of cocktails for blocking glutamate transmission in brain slice preparation.
Biochem/physiol Actions
Primary Target
Grup I and II mGlu receptors
Grup I and II mGlu receptors
Target IC50: 40 and 15 →M for mGlu₁ and mGlu₂, respectively.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Fano, S., et al. 2012. Eur. J. Neurosci.36, 3628.
Wang, W., et al. 2012. J. Physiol.590, 3743.
Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646.Schoepp, D.D., et al. 1999.
Neuropharmacol.38, 1431.
Wang, W., et al. 2012. J. Physiol.590, 3743.
Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646.Schoepp, D.D., et al. 1999.
Neuropharmacol.38, 1431.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
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