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5.04658

LY 367385 Hydrochloride

Name: LY 367385 Hydrochloride
Brand: MM

Synonym(s):

LY 367385 Hydrochloride, (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₁NO₄ · xHCl

CAS Number:

198419-91-9

Molecular Weight:

209.20 (free base basis)

UNSPSC Code:

12352200

Assay

≥98% (HPLC)

Quality Level

100

form

powder

potency

8.8 μM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

white

solubility

H₂O: 18 mg/mL

storage temp.

2-8°C

InChI

1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1

InChI key

SGIKDIUCJAUSRD-QMMMGPOBSA-N

General description

A potent antagonist selective for mGlu_1a receptors (IC₅₀ = 8.8 µM and >100 µM for mGlu_1a and mGlu_5a, respectively). Negligible effect on group II and III mGlu receptors. Frequently used in studies assessing the functional roles of mGlu_1a in various brain functions and disorders in which neural transmissions via mGlu_1a receptors are involved.

Biochem/physiol Actions

Primary Target
mGlu₁ receptors

Physical form

Supplied as a hydrochloride salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Young, R., et al. 2013. J. Neurosci.33, 2526.
Chapman, A., et al. 1999. Eur. J. Pharmacol.368, 17.
Bruno, V., et al. 1999. Neuropharmacol.38, 199.

Clark, X., et al. 1997. Bioorg. Med. Chem. Lett.7, 2777.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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