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Merck

5.04685

LY 354740

Synonym(s):

LY 354740, (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad

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About This Item

Empirical Formula (Hill Notation):
C8H11NO4
CAS Number:
176199-48-7
Molecular Weight:
185.18
UNSPSC Code:
12352200

Assay

≥99% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

1 M NaOH: 100 mM

storage temp.

2-8°C

InChI

1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1

InChI key

VTAARTQTOOYTES-RGDLXGNYSA-N

General description

A highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100 µM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep.

Biochem/physiol Actions

Primary Target
mGlu2/3 receptors

Packaging

Yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Siok, J., et al. 2012. Neuropharmacol.62, 226.
Fell, J., et al. 2012. Neuropharmacol.62, 1473.
Pilc, A., 2003. IDrugs.6, 71.
Klodzinska. A., 1999. Neuropharmacol.38, 1831.
Monn, J., 1997. J. Med. Chem.40, 528.
Schoepp, D., 1997. Neuropharmacol.36, 1.
Bond, A., 1997. Neuroreport.8, 1463.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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