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Merck

5.04745

AMN082 Dihydrochloride

Synonym(s):

AMN082 Dihydrochloride, N,N′-Dibenzhydrylethane-1,2-diamine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C28H28N2 · 2HCl
CAS Number:
97075-46-2
Molecular Weight:
465.46
UNSPSC Code:
12352200
MDL number:
MFCD08702723
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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InChI

1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H

InChI key

YRQCDCNQANSUPB-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mM

storage temp.

−20°C

Quality Level

100

General description

A potent, selective and systemically active positive allosteric modulator for mGlu7 receptor (EC50 = 64-290 nM). One of the most frequently used agent for assessing the functional roles of mGlu7 receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinson′s disease). Induces internalization of mGlu7 receptors. Also acts on NMDA, AMPA, 5-HT receptors and norepinephrine transporter.

Biochem/physiol Actions

Primary Target
mGlu₇ receptors

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Cavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.

Flor, X., et al. 2005. Neuropharmacology 49, 244.
Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.

Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.

Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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