5.04746
Idazoxan Hydrochloride
동의어(들):
Idazoxan Hydrochloride, 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride, RX781094, Idazoxa, α2-Adrenoceptor Antagonist, Idazoxan Hydrochloride
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C11H12N2O2 · xHCl
CAS 번호:
Molecular Weight:
204.23 (free base basis)
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
assay
≥98% (TLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 50 mg/mL
storage temp.
10-30°C
InChI
1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
InChI key
MYUBYOVCLMEAOH-UHFFFAOYSA-N
General description
A non-selective antagonist for α2-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for α2A, α2B, and α2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I1 and I2, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors.
A non-selective antagonist for ?2-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for ?2A, ?2B, and ?2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I1 and I2, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors.
Biochem/physiol Actions
Primary Target
→₂-adrenoceptor
→₂-adrenoceptor
Preparation Note
Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Humpston, S., et al. 2013. J. of Psychopharmacology, 27, 213.
Dabir, l., 1986. J.Pharmacol.17, 113.
Michel, M., et al. 1992. TIPS13, 369.
Eglen, R., et al. 1998. TiPS19, 381.
Doxey, J., et al. 1984. Br J Pharmacol. 1984. 83, 713.
Gadie, B., 1984. Br J Pharmacol.83, 707.
Dabir, l., 1986. J.Pharmacol.17, 113.
Michel, M., et al. 1992. TIPS13, 369.
Eglen, R., et al. 1998. TiPS19, 381.
Doxey, J., et al. 1984. Br J Pharmacol. 1984. 83, 713.
Gadie, B., 1984. Br J Pharmacol.83, 707.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.