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5.04746

Idazoxan Hydrochloride

Synonym(s):

Idazoxan Hydrochloride, 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride, RX781094, Idazoxa, α2-Adrenoceptor Antagonist, Idazoxan Hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H12N2O2 · xHCl
CAS Number:
79944-56-2
Molecular Weight:
204.23 (free base basis)
UNSPSC Code:
12352200
MDL number:
MFCD00069293
Assay:
≥98% (TLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light
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assay

≥98% (TLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 50 mg/mL

storage temp.

10-30°C

InChI

1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H

InChI key

MYUBYOVCLMEAOH-UHFFFAOYSA-N

General description

A non-selective antagonist for α2-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for α2A, α2B, and α2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I1 and I2, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors.
A non-selective antagonist for ?2-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for ?2A, ?2B, and ?2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I1 and I2, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors.

Biochem/physiol Actions

Primary Target
→₂-adrenoceptor

Preparation Note

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Humpston, S., et al. 2013. J. of Psychopharmacology, 27, 213.
Dabir, l., 1986. J.Pharmacol.17, 113.
Michel, M., et al. 1992. TIPS13, 369.
Eglen, R., et al. 1998. TiPS19, 381.
Doxey, J., et al. 1984. Br J Pharmacol. 1984. 83, 713.
Gadie, B., 1984. Br J Pharmacol.83, 707.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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