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5.04777

Yohimbine Hydrochloride

Synonym(s):

Yohimbine Hydrochloride, 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride, α2-Adrenoceptor Antagonist, Yohimbine Hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H26N2O3 · xHCl
CAS Number:
65-19-0
Molecular Weight:
354.44 (free base basis)
UNSPSC Code:
12352200
MDL number:
MFCD00012674
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 25 mM

storage temp.

−20°C

InChI

1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/m0./s1

InChI key

PIPZGJSEDRMUAW-VJDCAHTMSA-N

General description

A potent antagonist for α2-adrenoceptors (pKi values are 8.52, 8.00 and 9.17 for human α2a, α2B and α2C receptors respectively). Often used as pharmacological stressor in animal studies.
Yohimbine Hydrochloride is a potent antagonist for α₂-adrenoceptors, α2B and α2C receptors respectively).

Biochem/physiol Actions

Primary Target
→₂-adrenoceptor

Preparation Note

Following reconstitution, aliquot and freeze (-20°c). Stock solutions are stable for up to 3 months at -20°C.
Slight warming is required for complete solubilization.

Other Notes

Calu, D., et al. 2013. J. Neurosci.33, 214.

Doxey, L., et al. 1984. Naunyn Schmiedebergs Arch. Pharmacol.325, 136.

Goldberg, K., et al. 1987. Pharmacol. Rev.35, 143.
Lalchandani, et al. 2002. J. Pharmacol. Exp. Ther.303, 979.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Certificates of Analysis (COA)

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