5.04839
(R)-CPP - CAS 126453-07-4 - Calbiochem
Synonym(s):
(R)-CPP - CAS 126453-07-4 - Calbiochem, (R)-3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid
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About This Item
Empirical Formula (Hill Notation):
C8H17N2O5P
CAS Number:
Molecular Weight:
252.20
UNSPSC Code:
12352200
form
solid
assay
≥98% (NMR)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
water: 100 mM
storage temp.
2-8°C
Biochem/physiol Actions
Primary Target
NMDA receptors
NMDA receptors
Target Ki: 0.041, 0.27, 0.63 and 1.99 →M for NMDA subtypes NR2A, NR2B, NR2C, and NR2D, respectively.
Disclaimer
Toxicity: Standard Handling (A)
General description
A highly potent antagonist slightly selective for NR2A over other subtype NMDA receptors (Ki = 0.041, 0.27, 0.63 and 1.99 µM for NMDA subtypes NR2A, NR2B, NR2C, and NR2D, respectively). Commonly used for various research in brain functions and disorders that neurotransmissions via NMDA receptors are involved.
Other Notes
Murphy, R., et al. 2012. Psychopharmacol.219, 401.
Paoletti, P., et al. 2007. Curr. Opin. Pharmacol.7, 47.
Feng, B., et al. 2004. Br. J. Pharmacol.141, 508.
Lowe, A., et al. 1990. Neurosci. Lett.113, 315.
Paoletti, P., et al. 2007. Curr. Opin. Pharmacol.7, 47.
Feng, B., et al. 2004. Br. J. Pharmacol.141, 508.
Lowe, A., et al. 1990. Neurosci. Lett.113, 315.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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