5,7-Dichlorokynurenic Acid, Sodium Salt

Name: 5,7-Dichlorokynurenic Acid, Sodium Salt
Brand: MM

Synonym(s):

5,7-Dichlorokynurenic Acid, Sodium Salt, 5,7-Dichloro-4-hydroxyquinoline-2-c-arboxylic acid sodium salt, DCKA

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₄Cl₂NNaO₃

CAS Number:

1184986-70-6

Molecular Weight:

280.04

MDL number:

MFCD00674925

UNSPSC Code:

12352106

NACRES:

NA.77

SMILES string

[Na+].Clc1c2c(nc(cc2O)C(=O)[O-])cc(c1)Cl

InChI

1S/C10H5Cl2NO3.Na/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14;/h1-3H,(H,13,14)(H,15,16);/q;+1/p-1

InChI key

VPRPMJHKWHCUFW-UHFFFAOYSA-M

assay

≥99% (HPLC)

form

solid

potency

79 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 10 mM
1 M NaOH: 100 mM

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Primary Target
NMDA receptors

Disclaimer

Toxicity: Standard Handling (A)

General description

A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (K_i = 79 nM vs. [3H]-glycine).

Other Notes

Baron, B., et al. 1991. Eur. J. Pharmacol.206, 149.
Baron, B., et al. 1990. Mol. Pharmacol.38, 554.
Mugnaini, M., et al. 1998. J. Recept. Signal Transduct. Res.18, 91.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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